Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance. 1.9 What recommendations has the federal government made to protect human health? Prioritization of substances based on a combination of their frequency, toxicity, and potential for human exposure at National Priorities List (NPL) sites. ANTIMONY. protozoic treatment. Water in PET bottles may contain higher levels of antimony. Toxicity Data: LD50 Oral – Rat >2,000 mg/kg . Usually, the toxic effects of metals are related to the chemical form to which peoples are exposed. At relatively low levels, lead can participate in synergistic toxicity with other toxic elements (e.g. It is also used in paints, ceramics, fireworks, enamels, and glass, and as a fire-retardant in textiles and plastics. Long-term occupational exposure of humans has resulted in electrocardiac disorders, respiratory disorders, and possibly increased mortality (Renes, 1953; Breiger et al., 1954). RTECS Number: CC9450000 . Antimony exists in valences of 0, -3, +3, +5. Blood concentrations in unexposed individuals rarely exceed 3 µg/L. profile for antimony, Agency for Toxic Substances and Disease Registry. Stibine is a metal hydride form of antimony us… In general, how your body reacts to a toxic level of antimony will depend on how you were exposed. Ainsworth et al. It is used in metal alloys, storage batteries, solder, sheet and pipe metal, ammunition, metal bearings, castings, and pewter. Treatment. Antimony is found in ores or other minerals, often combined with oxygen to form antimony trioxide or with sulfur to form stibnite. The information in this MRL serves as a screening tool to help public health professionals decide where to look more closely to evaluate possible risk of adverse health effects from human exposure. It roughly makes up about 0.00002 percent of the Earth’s crust. Note: Javascript is disabled or is not supported by your browser. recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. Toxicological Inhalation of antimony trioxide (and similar poorly soluble Sb(III) dust particles such as antimony dust) is considered harmful and suspected of causing cancer. Everyone is exposed to low levels of antimony in the environment. Email: Contact CDC-INFO. Provides an ongoing assessment of the exposure of the U.S. population to environmental chemicals using biomonitoring. DTXSID9061677 888-232-6348 (TTY) Antimony can exist in one of four valences in its various chemical and physical forms: -3, 0, +3, and +5. Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. Little antimony is currently mined in the United States. Antimony Trioxide (CASRN 1309-64-4) Superfund Health Risk Technical Support Center . The toxicology of antimony and its compounds is known from three sources: its medicinal use over centuries, studies of process workers in more recent times, and more recent still, studies of its presence in modern city environments and in domestic environments. Antimony occurs naturally in the earth. Antimony is a naturally occurring metal often used in combination with lead and zinc, found in metal alloys, paints, ceramics, and fireworks. Antimony levels for these occupational exposure evaluations ranged from 2.2 to 11.98 mg Sb/m 3. Little antimony is currently mined in the United States. Little antimony is currently mined in the United States. cadmium, mercury). This guide will inform you of sources of toxic heavy metals, symptoms of toxicity and how to remove them from your body. 7440-36-0. Methods: We included observational studies that measured levels of toxic metals (antimony, arsenic, cadmium, lead, manganese, mercury, nickel, silver, and thallium) in different specimens (whole blood, plasma, serum, red cells, hair and urine) for patients with ASD and for controls. 11. Decomposition Products: Antimony, antimony oxides, s ulfur oxides and hydrogen sulfide. Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. Basis for revised IDLH: The revised IDLH for antimony compounds is 50 mg Sb/m3 based on acute inhalation toxicity data in animals [Izmerov et al. Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. The form of antimony greatly influences distribution and elimination. Antimony levels as high as 9.7 µg/L have been reported in drinking water. EINECS 215-576-0. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, Health Effects of Exposure to Substances and Carcinogens, Community Environmental Health Education Presentations, Case Studies in Environmental Medicine (CSEM), Toxicology Curriculum for Communities Trainer's Manual, Compendium of Papers on MRLs and Health Effects, Agency for Toxic Substances and Disease Registry. It is brought into this country from other countries for processing. Those who breathed in the compound, like the port workers mentioned above, may suffer from symptoms like pneumoconiosis, gastrointestinal concerns, antimony spots appearing on their skin, and respiratory irritation. Antimony oxide (Sb2O4) Diantimony tetraoxide. The tri- and pentavalent forms are the most stable forms of antimony (U.S. EPA, 1992) and are of the most interest in biological systems. 1.8 Is there a medical test to determine whether I have been exposed to Antimony? Urine testing is the most accurate, reliable, and valid test method for measuring antimony levels in the body. Ingestion. of antimony toxicity wherein 30 firefighters reported elevated antimony levels on hair analyses as some fire fighter station uniforms contain the flame-retardant antimony trioxide. Antimony pentasulphide (Sb 2 S 5) has much the same uses as the trisulphide and has a low level of toxicity. Symptomatic and supportive treatment is most commonly used in antimony toxicity. Quick reference guide providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects for a substance. Profile for antimony, Toxicological Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. Antimony is a toxic heavy metal to humans and has serious health implications for those that may be toxic with antimony. It is brought into this country from other countries for processing. The effects are hypothesized to be attributed to inhalation of poorly solubl… The effects of antimony and its compounds on human and environmental health differ widely. You … Antimony: A silvery-white earth metal which at high levels can be toxic. Antimony oxide is added to textiles and plastics to prevent them from catching fire. As covered in a recent article, Toxic Chemicals in Children’s Toys, it is one of eight heavy metals limited by the CPSC in the manufacture of products for children 12 years old or younger. CDC has established ranges for urine levels of antimony in the U.S. population: 0.120–0.364 micrograms/gram creatinine. Toxicological Information . Other Therapies Antimony is a silvery-white metal that is found in the earth's crust. Skin contact. Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. 1.2 What happens to Antimony when it enters the environment? Based on limited data, occupational exposure of women to metallic antimony and several antimonials has reportedly … The most widely used antimony compound is antimony trioxide, used as a component in flame retardant applications. ANTIMONY TETROXIDE. Antimony poisoning has resulted from drinking acidic fruit juices containing antimony oxide dissolved from the glaze of cheap enamelware containers. Antimony isn't used alone because it breaks easily, but when mixed into alloys, it is used in lead storage batteries, solder, sheet and pipe metal, bearings, castings, and pewter. Antimony is a rare element part of the metalloid group in the periodic table. However, these effects are only observed with female rats and after long-term exposure to high dust concentrations. Antimony is used for hardening lead, and in the manufacture of batteries and cables. However, there are companies in the United States that produce antimony as a by-product of smelting lead and other metals. [] conducted several laboratory experiments to investigate whether elevated antimony concentrations previously found in the organs of wild, short-tailed field voles (Microtus agrestis) at a contaminated grassland site near an antimony smelter were sufficient to cause harmful … In accordance with the diantimony trioxide CSR, the NOAEL of 1686 mg/kg bw/d from a subchronic oral toxicity study in rats is selected as being the most relevant for estimating systemic effects that might be associated with dermal uptake of antimony metal or antimony (III) compounds. Gross exposure to antimony compounds o … For this reason, some items on this page will be unavailable. Note: Javascript is disabled or is not supported by your browser. ... Kim et al. 1982] and an analogy to hydrogen chloride [ACGIH 1991] which has a revised IDLH of 50 ppm (75 mg/m3). When your body accumulates antimony over time it influences and raises your blood cholesterol while at the same time can decrease your blood sugar level. Hazard Summary. Acute (short-term) exposure to antimony by inhalation in humans results in effects on the skin and eyes. Summary of mammalian toxicity Mammalian Oral Toxicity Mammalian Oral Toxicity—Acute. It is brought into this country from other countries for processing. Elemental antimony metal does not affect human and environmental health. Antimony is used as a part of the therapy for these conditions and can sometimes have toxic side effects that lead to pancreatitis and cardio toxicity. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry. Heavy metals are deadly hidden toxins in our food and environment. According to an article done by De Wolffe, a professor of toxicology at thew University of Amsterdam, antimony toxicity does not exist; and every compound of the metal must be considered to be a separate toxicological entity. Routes Of Exposure: Eye contact. The level in urine is normally around 250 ppt (which is equivalent to a mere 0.000000025%). Fact sheet that answers the most frequently asked questions about a contaminant and its health effects. Inhalation. Chelation Therapy; Chelation therapy with BAL, DMSA, or DMPS has been shown to improve the course of antimony toxicity. Summary: Antimony is a silvery-white metal that is found in the earth's crust. Provisional Peer Reviewed Toxicity Values for . Antimony trichloride (SbCl 3 ), or antimonous chloride (butter of antimony) , is produced by the interaction of chlorine and antimony or by dissolving antimony trisulphide in hydrochloric acid. Blood antimony levels predominantly reflect recent exposure and are most useful in the diagnosis of acute poisoning. Common symptoms of poisoning from these metals may include gastrointestinal, renal, and neurological symptoms, such as headaches, irritability, psychosis, stupor, coma, and convulsions. The study The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. Antimony is a silvery-white metal that is found in the earth's crust. It is also used in paints, ceramics, and fireworks, and as enamels for plastics, metal, and glass. However, no It is also used as a catalyst to produce polyester, and is found in plastics used for disposable beverage bottles. Symptoms of antimony poisoning, when exposed to small doses, include headache, nausea, and depression. In certain cases when the Antimony levels are higher than expected, the associated … ATSDR can also tell you the location of occupational and environmental health clinics. However, even these doses can be fatal when chronically exposed. The background level of antimony in bodily fluids used to be almost undetectable but techniques have improved in recent years so that it is now measurable at parts per trillion. TESTING: If you suspect that you have an elevated Lead level, it is important for you to know that whole blood analysis can reflect only recent exposures and does not correlate well with total body burden of lead. Health Dangers of Antimony. For this reason, some items on this page will be unavailable. Blood levels of antimony can be measured to confirm diagnosis of antimony toxicity. Chronic Toxic Effects: This product ha s not been fully tested. In general, how your body reacts to a toxic level of antimony will depend on how you were exposed. Antimony is a metalloid with an atomic number of 51. (1999) evaluated serum cytokine and immunoglobulin levels in antimony workers at a factory in Korea that produced antimony trioxide as a major product. 1.4 How can Antimony enter and leave my body? The metal is usually alloyed with other alloys to increase its viability in the manufacturing industry where it is used to help make certain semiconductor devices. This practice has been largely discontinued as a result of antimony toxicity. These clinics specialize in The toxicokinetics and toxicity of the tri- and pentavalent forms vary, with the trivalent form considered to be more toxic. The CDC stated in their report that only validated methods should be used for the determination of antimony toxicity. 1.7 How can families reduce the risk of exposure to Antimony? Inhalation in humans results in effects on the skin and eyes product ha not... In recognizing, evaluating, and as a catalyst to produce polyester and! 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